Myelosuppressive toxicity of chemotherapy

Chemical treatment of cancer may affect normal bone marrow cells. The degree of influence of each chemical to bone marrow depends on many factors such as age, level of conservation of the bone marrow, affecting the level of the previous chemical treatments and nutritional status of patients. In many cases, bone marrow suppression is dose dependent. Thus, inhibition of bone marrow toxicity limits the dose of chemical use and thus affect treatment efficacy.

Demographics

Chemotherapy will cause reduction of leukemia cell lines, platelets and in a lesser degree in the erythrocytes in the blood stream. This effect usually occurs after a few days use of chemicals and usually start recovery after 10-14 days.

Reduced neutrophil is the main contributing factor to infection, reduced or limited dose combination for the treatment chemicals. There is a very close correlation between the duration of neutropenia and severity of neutropenia with infection: the number of neutrophils in the peripheral blood <1,000 / mm3 happens in infection over 50% of patients and the proportion increases rapidly as the number of neutropenia <500 / mm3. Currently kiich factors like line (G-CSF, GM-CSF) is responsible for controlling growth, differentiation and maturation of neutrophils and macrophages has been produced by recombinant techniques DNA and is widely used in clinical treatment DRR impaired neutrophil by chemical treatments. Especially G -CSF (granulo – colony stimulating factor) stimulates the cells that line, driving the growth and differentiation of precursor cells into neutrophil neutrophil cells mature and strengthen the entry of cells into peripheral blood. So G-CSF may increase the number of neutrophils in a short time, shortening of neutropenia and thus help ensure the dose and duration of chemotherapy.

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